Endocrine Abstracts

Introduction: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that arises from the parafollicular C-cells of the thyroid gland with a tendency to regional and distant metastases. It is a rare tumor, making up about 3% of all thyroid malignancies. MTC occurs in both heritable and sporadic forms, early diagnosis is important as it can improve treatment outcomes. We report a case of metastatic medullary thyroid cancer with both diagnostic and therapeutic challenges. <...

Introduction: Pituitary adenomas are rare in infants and adolescents. Prolactinomas account for 50% of these pituitary adenomas. In adolescent girls, it is usually a microprolactinoma revealed by puberty delay or amenorrhea. We report a rare case of a macroprolactinoma in an adolescent girl revealed by visual impairment.Case presentation: A 15-year-old adolescent girl presented with loss of vision over a long period of time. Magnetic resonance imaging re...

Introduction: Ganglioneuroma (GN) is a benign, well-differentiated nerve tumor composed of mature sympathetic ganglion cells and nerve fibers, and most commonly located in the posterior mediastinum and retroperitoneum. GN’s are rarely found in the adrenal gland. This tumor is usually asymptomatic and, in the majority of cases, detected incidentally. The diagnostic confirmation is histologic. We report a case of adrenal GN revealed by an adrenal incidentaloma.<p class=...

Introduction: Autoimmune polyendocrinopathy syndrome (APS) type 4 is rare, characterized by an association between an autoimmune endocrine disease with another endocrine or non-endocrine autoimmune disease, and this association cannot be attributed to APS type 2 or 3. We report the observations of 3 cases with APS type 4.Cases presentations: Case N 1:Patient 16 years old, type 1 diabetic for 9 years under insulin therapy, with...

Introduction: The association of multi-organ autoimmune diseases is described. We report a case of association between Latent autoimmune diabetes in adults (LADA) and systemic scleroderma (SSc), which remains a rarely reported entity in the literature.Observation: 38-year-old female patient, followed for systemic scleroderma with digestive and pulmonary involvements. The patient presented a dysphagia to solids with dyspnea installed in the last 2 months,...

Introduction: Mitochondrial diabetes represents about 1% of diabetes but still very often misunderstood. The most frequent mutation is 3243A >G of the mtDNA, which is responsible for the maternally inherited diabetes and deafness syndrome (MIDD). We report an observation of a patient with strong suspicion of mitochondrial diabetes.Case presentation: 43-year-old female patient, with diabetes for 5 years on an Insulin Therapy.Anamnesis:&hypen;&...

Introduction: The association of multi-organ autoimmune disorders is described. We report a case of Hashimoto’s thyroiditis (HT) and primary biliary cholangitis (PBC), both are a chronic autoimmune inflammation, with lymphocytic infiltration and destruction of thyroid cells for (HT) and progressive destruction of intrahepatic bile ducts leading to cirrhosis for (PBC)Case report: 54-year-old female patient, followed for (PBC) at cirrhosis stage admit...

Introduction: Benzold abscess remains rare, and its occurrence implies immunosuppression, particularly within unbalanced diabetes.Methods and Results: Observation of a 76-year-old patient, diabetic for 29 years, on metformin, admitted for CMO of the right ear, complicated by Bezold’s abscess. The interrogation revealed purulent otorrhea hypoacusis. The clinical examination revealed hyperglycemia, a swelling of the sternocleidomastoid, responsible fo...

Introduction: Human immunodeficiency virus (HIV) infection and certain antiretroviral (ARV) treatments are associated with an increased risk of developing certain chronic comorbidities including type 2 diabetes, which is more prevalent in HIV-infected individuals. The coexistence of diabetes and HIV infection makes the standard of care more complex. The objective of this work is to discuss the relationship between these two comorbidities and to update physicians on the diagnos...

Introduction: Familial neurohypophysial diabetes insipidus (FNDI), an autosomal dominant disorder, comes in many forms that are differentiated by the inheritance pattern and the underlying genetic lesion. The disease is caused by mutations in the vasopressin-neurophysin 2-copeptin protein (AVP-NPII), in wolframin (WFS1) or in proprotein convertase subtilisin/kexin type 1 (PCSK1) genes.Materials and methods: In this study, we report a case of familial neu...